Manor Tavern is located on a land that was once the home of the Piscantaway Indians. The tribe's trail, now Old York Road, was a major North-South artery between Washington, D.C. and Philadelphia. Passing through in 1687, Charles Calvert, the third Lord Baltimore, decreed 10,000 acres for himself. He made a gift of this land to his fourth wife in 1713, christening the estate "My Lady's Manor".

With the construction of St. James Church in 1750, inns, taverns, stables and blacksmith shops sprang up along the Manor route to accommodate the many travelers. Slade's Tavern was a popular inn and public house; George Washington stayed there frequently during his trips from Mt. Vernon to Philadelphia. Located across the street from Slade's, Manor Tavern's site was a stable for guest horses.

Since it's beginnings as a stable, Manor Tavern has experienced many colorful transitions, from dirt-floor saloon - featuring cockfights, gamblers and poolroom donnybrooks - to today's horse-country gem. In 1986, Manor Tavern officially emerged as a full-service restaurant with banquet facilities.